the recommended dose of gemcitabine for adult is 1000 mg/m2 as an intravenous infusion over 30 minutes once a week for three consecutive weeks, followed by a week of rest, repeated every four weeks. the dose is reduced accordingly according to the patient's toxicity.
preparation method: add at least 25 ml of 0.9% sodium chloride injection to the vial (containing gemcitabine 1.0 g), the dilution yields a gemcitabine concentration of not more than 40 mg/ml, shake to dissolve. prior to administration the
required amount of drug must be diluted with 0.9% sodium chloride injection.
the prepared gemcitabine solution should be stored at room temperature and used within 24 hours. the gemcitabine solution should not be refrigerated to prevent crystal precipitation.
geriatric use: older patients over the age of 65 can also be well tolerated. although age has an effect on the clearance and half-life of gemcitabine, there is no evidence that older patients need to adjust the dose.
pediatric use: the safety and effectiveness of gemcitabine have not been established in pediatric patients.